I just testified at a public FDA hearing on a new drug for hyponatremia (low sodium)--a simultaneously fascinating and frustrating experience.
When one of the FDA's Advisory Committee members commented that "we shouldn't be just treating a number, we need to know that we're treating the problem," I realized that I was in a bizarre time warp. As a geriatrician, I've wanted to hear doctors say this for my entire career. Today, however, this meant that I might be denied a tool to treat a problem for which I essentially have no tools. As a clinician who deals with a very complex frail population of patients, I want some options from which to make clinical decisions.